The World Economic Forum (2015) rates food crises, extreme weather and failure of infrastructure as top global risks in 2015. Around the world, regions are contending with extreme weather, including drought, flooding and changes in growing seasons. These extremes affect crops and pests, and may disrupt agriculture and its supply chains, especially in the second half of this century. This paper presents an example of how transportation of agricultural products in the Upper Mississippi River Valley region of the United States may be impacted by, and respond to, a changing climate.